Iontophoresis
Iontophoresis is a non-invasive technique that uses a mild electric current to deliver drugs through the skin. Drugs may be delivered either into tissue immediately surrounding a patch for local delivery, or into the blood stream for systemic delivery.

Vyteris technology
How the Vyteris Drug Delivery System Works
Unique Advantages of Active Transdermal
Demonstrating the Versatility
Clinical Applications
Safety of Iontophoresis

Vyteris' Technology Back to topTop
Our proprietary technology is the result of over 10 years of research. The result is an active, transdermal drug delivery platform employing an adhesive patch containing medication and a small electronic dose controller. The patch consists of two pre-loaded reservoirs, a drug reservoir that contains the drug to be delivered and a return reservoir with saline to complete the circuit. The controller contains a battery and a preprogrammed microcomputer to control the electrical charge. The two components connect through an interface. The product shown in the picture to the right is our Lidocaine Delivery System, future product designs can be configured to meet the needs of the specific application.



How the Vyteris Drug Delivery System Works Back to topTop



Unique Advantages of Active Transdermal  Back to topTop
Advantages over Injection Advantages over Oral Advantages over Passive Transdermal
 
  
No pain and swelling at injection site
Discrete and convenient
Improve patient compliance
Controllable dosing profile - Control the rate, dosage and pattern of drug delivery across the skin, as well as record the amount and time of drug delivered
 
  
Reducing GI Side-Effects
Avoids first pass metabolism
Eliminates multiple dosing per day
Eliminates dose fluctuation due to diet
 
  
Faster onset of action
Higher drug delivery efficiency
Ability to deliver a wide variety of drugs including peptides
Controllable dosing profile - Control the rate, dosage and pattern of drug delivery across the skin, as well as record the amount and time of drug delivered

Demonstrating the Versatility Back to topTop
The technology can mimic other delivery routes and provide a wide range of tightly-controlled dosing profiles. In Chart 1 we have matched the IV infusion of a peptodomimeic delivery in man with our active transdermal drug delivery system. The three charts below demonstrate other dosing profiles we are capable of delivering.




Clinical Applications Back to topTop
There are numerous applications for our drug delivery system in treating a variety of diseases. The chart below demonstrates the benefits of our drug delivery technology on various clinical applications.


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Safety of Iontophoresis Back to topTop
Vyteris iontophoresis systems have been shown to cause only mild transient erythema when used with both placebo patches and for the vast majority of drugs tested. This has been shown through multiple trials involving hundreds of subjects, a variety of drugs, and numerous operation parameters, including patch size, delivery duration and electric current.

 
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